日本众多研究机构相继开展LPS作为药物和疫苗的临床研究:
-当地上师范大学科学专业硕士院医药学专业部
京都上师范大学回收医药学专业科学探究所-顺天堂图片大家 -日本地区国家的完美转型发展中介机构-日式成为1400万种医疗耗材巨型海洋生物制作药品集团Cosmo Bio集团
其他发达国家对LPS相关研究:
-近几天高度发达政府过敏症状的加大是犹豫LPS展现的下降Environmental exposure to endotoxin and its relation to asthma in school-age children. Braun-Fahrländer C, Riedler J, Herz U, Eder W, Waser M, Grize L, Maisch S, Carr D, Gerlach F, Bufe A, Lauener RP, Schierl R, Renz H, Nowak D, von Mutius E; Allergy and Endotoxin Study Team. The New England Journal of Medicine 347 (12): 869-77 (2002)
-LPS的舌下给药减弱了病毒性流感役苗的功能A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway. Fukasaka M, Asari D, Kiyotoh E, Okazaki A, Gomi Y, Tanimoto T, Takeuchi O, Akira S, Hori M. PLoS One 10 (5): e0126849.
-LPS的去炎症功用被证明怎么写是与调节器性T神经元(Tregs)有观Lipopolysaccharide-activated CD4+CD25+ T regulatory cells inhibit neutrophil function and promote their apoptosis and death. Lewkowicz P, Lewkowicz N, Sasiak A, Tchórzewski H. J Immunol. 177 (10): 7155-7163 (2006)
-四环素给药削减身胃中部抗产气荚膜梭菌制品剂的有并提高四环素抗性菌类,但口服药LPS和四环素应该介导身胃中部抗真菌化合物并能够抑制抗性菌类的萌发。 Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits. Brandl K, Plitas G, Mihu CN, Ubeda C, Jia T, Fleisher M, Schnabl B, DeMatteo RP, Pamer EG. Nature 455 (7214): 804-807 (2008)
-四环素减轻了胃癌免疫细胞辽法的高效性性,但LPS制止了它 Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, Molina DA, Salcedo R, Back T, Cramer S, Dai RM, Kiu H, Cardone M, Naik S, Patri AK, Wang E, Marincola FM, Frank KM, Belkaid Y, Trinchieri G, Goldszmid RS. Science 342 (6161): 967-970 (2013)
-LPS有机会做为免疫力性汉方药“十全大补汤”的免疫力性激话的一两个分为这部分 Uncovering potential 'herbal probiotics' in Juzen-taiho-to through the study of associated bacterial populations. Montenegro D, Kalpana K, Chrissian C, Sharma A, Takaoka A, Iacovidou M, Soll CE, Aminova O, Heguy A, Cohen L, Shen S, Kawamura A. Bioorg Med Chem Lett 25 (3): 466–469 (2015)